Clinical study on the autoimmune antibodies and endocrine hormones in patients with endometriosis complicated with infertility / 中国基层医药

ABSTRACT

Objective To explore the levels of autoimmune antibodies and endocrine hormones in patients with endometriosis complicated with infertiilty.Methods 158 endometriosis and infertility patients were selected as study subjects,and they were divided into endometriosis complicated with infertility group(A group,52 cases),endometriosis group(B group,50 cases) and infertility group(C group,56 cases) according to the type of disease.At the same time,93 healthy women were selected as control group.The autoimmune antibodies such as anti-endometrial antibody(EMAb),anti-chorionic gonadotropin antibody(HCGAb),anti-sperm antibody(ASAb),anti-cardiolipin antibody(ACAb) and anti-ovarian antibody(AOAb),endocrine hormones such as luteinizing hormone(LH),follicle stimulating hormone(FSH),prolactin(PRL),estradiol(E2),insulin(INS) and testosterone(T) were compared in four groups.Results There was no significant difference in the total antibody positive rate between B group and C group (χ2=2.161,P＞0.05).The total antibody positive rate of A group was significantly higher than that of B,C group and the control group,the difference was statistically significant(χ2=6.316,P＜0.05).The PRL and INS levels of A group were much higher than those of B,C group and the control group,the differences were statistically significant(F=15.625,10.431,all P＜0.05).The E2,INS and PRL levels of B group were much higher than those of C group and the control group(F=10.363,9.515,9.037,all P＜0.05).The E2,T,INS and PRL levels of A group were much higher than those of B and C group,the differences were statistically significant (F=5.029,6.225,6.631,7.106,all P＜0.05).The LH and FSH levels of the four groups had no significant differences(F=2.385,2.531,all P＞0.05).There were no significant differences in all of the endocrine hormones between C group and the control group(t=1.535,0.931,0.825,1.363,1.005,1.259,all P＞0.05).Conclusion The main factors that cause endometriosis patients complicated with infertility may be due to a endometriosis immune imbalance of T,E2 and PRL and endocrine abnormalities,through the analysis of the levels of autoimmune antibodies and endocrine hormones can provide a reliable basis for clinical.