Self renewal, repair and malignant transformation of intestine epithelial cells / 实用肿瘤学杂志

ABSTRACT

Chronic inflammation of intestine mucosal has been considered as a critical component of colorectal cancer development.Recently,the studies based on high throughput sequencing of colorectal cancer patients released a potential molecular subtype of colorectal cancer,characterized by wound healing and innate immune genes.It suggests that a probably mechanism described by a subset of cells that may be dependent on inflammatory cells and cytokines of tumor development,extremely expanding our insight of cell malignant transformation,and highlight the anti-inflammation treatment.This article will review the normal mechanism of intestine mucosal renewal,wound healing and malignant transformation.