Risk factors of hemorrhagic fever with renal syndrome in children and adolescents in Xi'an City, Shaanxi Province: a case-control study / 中华地方病学杂志

ABSTRACT

Objective To study the risk factors of hemorrhagic fever with renal syndrome (HFRS) in children and adolescents in Xi'an City.Methods HFRS laboratory confirmed cases aged under 16 from January 2013-December 2015 were selected,which were reported by Information System of Disease Prevention and Control of the People's Republic of China.A 11 matched case-control study was adopted to retrospective investigate the risk factors.Logistic regression analysis was used to analyze relationships between various factors and HFRS in single factor analysis,the influence factors in the single factor analysis with statistical significances were further analyzed in the multiple factors analysis.Results Eighty-eight matched pairs were investigated.Single factor Logistic regression analysis found that non-nuclear family [odds ratio (OR) =20.25,95％ confidence interval (CI)2.32-76.80],less hand washing frequency before meals (OR =3.67,95％CI1.40-9.62),the river or pond around the place (OR =1.55,95％CI1.32-2.94),sit on the hay and play (OR =1.36,95％CI1.17-1.80),eating in the snack bar (OR =8.33,95％CI1.78-9.47),do not spray water when sweeping the floor (OR =2.22,95％CI1.24-4.12),living in the edge of village (OR =1.55,95％CI1.32-2.94),and keeping pets in the home (OR =12.00,95％CI1.12-28.84) were associated with HFRS.In multiple factors Logistic regression analysis,risk factors according to the contribution value from high to low in the order were keeping pets in the home (OR =5.40,95％CI1.78-16.32),less hand washing frequency before meals (OR =3.96,95％CI1.89-7.23),living in the edge of village (OR =2.42,95％CI1.82-5.50),and the river or pond around the place (OR =2.21,95％CI1.86-2.49).Conclusion Risk factors as keeping pets in the home,less hand washing frequency before meals,living in the edge of village,the river or pond around the place are likely risk factors of HFRS.