Neutrophil extracellular traps and coagulation dysfunction in sepsis / 中华危重病急救医学
Chinese Critical Care Medicine
;
(12): 752-755, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-618134
ABSTRACT
Neutrophil extracellular traps (NETs) are net-like structure composed of DNA and nuclear proteins, which are produced by activated neutrophils under the circumstances of a variety of pathogens or drugs. As part of defensive mechanism, NETs have been proved to restrict the spread of pathogens and release of antimicrobial molecules. NETs can not only strengthen the adhesion between neutrophils and platelets, promote platelet mediated procoagulant reaction, but also lead to endothelial cell damage and coagulopathy in sepsis. In addition, NETs also plays an important role in pathophysiological processes of venous thrombosis. Therefore, NETs may become the biomarkers of evaluating coagulation dysfunction and potential therapy target in sepsis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Critical Care Medicine
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS