Therapeutic effects of angiotensin receptor blocker irbesartan on hypertension and its compliance / 心血管康复医学杂志

ABSTRACT

Objective: To explore therapeutic effects of angiotensin receptor blocker (irbesartan) on hypertension and its compliance.Methods: A total of 200 cases with hypertension treated in our hospital were selected, randomly and equally divided into atenolol group and irbesartan group.Therapeutic effect, levels of blood pressure and blood lipids, and hemodynamic indexes were compared between two groups after treatment.Results:After treatment, total effective rate of irbesartan group was significantly higher than that of atenolol group (98.0% vs.72.0%, P=0.001).Compared with atenolol group, there were significant reductions in systolic blood pressure [(131.5±8.4)mmHg vs.(122.2±7.5) mmHg], diastolic blood pressure [(122.2±7.5)mmHg vs.(83.6±4.4) mmHg],blood triglyceride level [(7.5±1.5)mmol/L vs.(5.2±1.2)mmol/L], whole blood high shear viscosity [(6.7±0.7)mPa·s vs.(6.1±0.4)mPa·s], whole blood low shear viscosity [(10.5±0.7) mPa s vs.(9.2±0.6)mPa s] and plasma high shear viscosity [(1.9±0.2) mPa s vs.(1.5±0.1) mPa s] in irbesartan group, P<0.01 all.Therapeutic compliance of irbesartan group was significantly higher than that of atenolol group (95.0% vs.63.0%, P=0.001).Conclusion: Angiotensin receptor blockers irbesartan possess significant therapeutic effect on patients with hypertension.It is safe and reliable with high compliance, which is worth extending.