Expression of CtBP1, Zeb1, Zeb2 and E-cadherin in cholangiocarcinoma and their clinical significance / 临床与实验病理学杂志
Chinese Journal of Clinical and Experimental Pathology
;
(12): 365-369, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-618361
ABSTRACT
Purpose To investigate the expression of transcriptional suppressor CtBP1,Zeb1,Zeb2 and their target gene E-cadherin,and their significance in cholangiocarcinoma.Methods The expression of CtBP1,Zeb1,Zeb2 and E-cadherin proteins in cholangiocarcinoma and the paired non-neoplastic tissue array were detected by the immunohistohemical staining.Results The positive rates of CtBP1 expression in cholangiocarcinoma and the paired non-neoplastic tissue were 44.44% and 17.86%,these of Zeb2 were 34.92% and 10.71%,and these of E-cadherin were 50.79% and 100%,respectively.The differences between the groups were statistically significant (all P < 0.05).There was only one case with expression of Zeb1 in cholangiocarcinoma,but no expression in the paired non-neoplastic tissue.CtBP1 was correlated with the degree of differentiation of cholangiocarcinoma (P < 0.05).Ecadherin was related to the differentiation degree,and distant metastasis of cholangiocarcinoma (all P < 0.05).The E-cadherin expression was negatively correlated with CtBP1 and Zeb2 (r =-0.034,-0.029,all P < 0.05).The Zeb2 expression was positively correlated with CtBP1 (r =0.228,P =0.005).Conclusion CtBP1,Zeb2 and E-cadherin express abnormally in cholangiocarcinoma.CtBP1,Zeb2 may be involved in the regulation of E-cadherin expression.Joint detection of CtBP1 and Ecadherin is expected to be a reference index to evaluate the malignant biological behavior of cholangiocarcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical and Experimental Pathology
Year:
2017
Type:
Article
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