The role of RyR2 phosphorylation in heart failure / 复旦学报(医学版)
Fudan University Journal of Medical Sciences
;
(6): 359-362, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-618385
ABSTRACT
Heart failure is mainly characterized by myocardial systolic dysfunction,which is based on excitement-contraction coupling on the cellular level,and calcium (Ca2+) signaling plays a very important role in this process.The ryanodine receptor (RyR)/calcium release channel on the sarcoplasmic reticulum (SR) is the major Ca2+ source of required for cardiac muscle excitation contraction coupling.RyR2 phosphorylation is the basis of SR calcium release,and RyR2 phosphorylation is mainly controled by protein kinase A (PKA) and calcium/calmodulin dependent protein kinase Ⅱ (CaMK Ⅱ).Although widely research in this area,excessive activation of RyR2 phosphorylation involved in the pathogenesis of heart failure are still controversial,which is discussed in this review.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Fudan University Journal of Medical Sciences
Year:
2017
Type:
Article
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