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Risk factor analysis for portal vein thrombosis in 591 patients with liver cirrhosis / 复旦学报(医学版)
Article in Zh | WPRIM | ID: wpr-618392
Responsible library: WPRO
ABSTRACT
Objective To observe the risk factors for portal vein thrombosis (PVT) in cirrhotic patients prior to receiving endoscopic treatment to prevent gastroesophageal varices rebleeding.Methods A retrospective analysis was conducted on cirrhotic patients admitted to Zhongshan Hospital,Fudan University from 2008 to 2013 for secondary prevention of gastroesophageal varices bleeding via endoscopic treatment.Relevant information and data were collected,followed by an univariate analysis and multiple Logistic regression analysis in attempt to identify potential factors affecting the formation of PVT.Results Totally 591 patients were enrolled in the present study and were classified as present-PVT group (n =122,20.64 %) and absent-PVT group (n =469,79.36 %).Univariate analysis showed that MELD score,hemoglobin,platelet count,total bilirubin,alanine aminotransferase,blood urea nitrogen,splenectomy ratio all achieved statistical significance between the two groups (P<0.05).The multiple Logistic regression showed that MELD score,lowered blood urea nitrogen,elevated D-dimer and history of splenectomy were independent factors associated with the formation of PVT (P values were separately 0.016,0.026,0.014 and <0.001).Conclusions Cirrhotic patients should receive regular surveillance for MELD score,liver function,D-dimer and portal vein ultrasonography,especially in patients received with a previous history of splenectomy.
Key words
Full text: 1 Index: WPRIM Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: Zh Journal: Fudan University Journal of Medical Sciences Year: 2017 Type: Article
Full text: 1 Index: WPRIM Type of study: Etiology_studies / Prognostic_studies / Risk_factors_studies Language: Zh Journal: Fudan University Journal of Medical Sciences Year: 2017 Type: Article