Deoxyadenosine antagonizes MTX-induced suppression of inflammatory bone destruction / 实用口腔医学杂志
Journal of Practical Stomatology
;
(6): 611-614, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-618621
ABSTRACT
Objective:
To study the effects of deoxyadenosine(dAdo) on methotrexate (MTX) induced suppression of inflammatory bone destruction.Methods:
The culture system of whole bone marrow cells (WBMCs) was utilized to evaluate osteoclastogenesis.TRAP staining and μCT analysis were utilized to evaluate osteoclastogenesis and bone destruction in adjuvant arthritis rats.Results:
In the bone marrow culture system,MTX-induced suppression of osteoclastogenesis was abrogated by the addition of dAdo.dAdo canceled MTX-induced suppression of osteoclastogenesis in the rats with arthritis,and significantly abolished the therapeutic effects of MTX on inflammatory bone destruction in the rats.Conclusion:
The accumulation of dAdo may be one cause of the losing effectiveness of MTX in bone destruction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Practical Stomatology
Year:
2016
Type:
Article
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