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The effect of Polygonatum Sibiricum Polysaccharide on the expression of OPG and RANKL in the rat model of ovariectomy-induced osteoporosis / 实用医学杂志
The Journal of Practical Medicine ; (24): 1243-1246, 2017.
Article in Zh | WPRIM | ID: wpr-619159
Responsible library: WPRO
ABSTRACT
Objective To investigate PSP on bone microstructures,Ca,P,OPG and RANKL of osteoporotic rat model.Methods Thirty female rats randomly divided into five groups:Sham,OVX,H-,M-,L-PSP.Sham and OVX were irrigated stomachsaline;PSP solution was gavaged to other groups.After 8-week,bone microstructures of tibial metaphyseal,Ca,P,OPG and RANKL were measured.Results Body weight,Ca,P,RANKL,Tb.Sp of OVX were significantly increased compared to Sham,OPG,BV/TV,Tb.Th,Tb.N decreased.Body weight of H-,M-PSP,Ca and Tb.Sp of PSP,P and RANKL in H-PSP were decreased compared to OVX,OPG in H-,M-PSP,BV/TV,Tb.Th,Tb.N of PSP group increased.The differences were statistically significant (P < 0.05).Conclusion PSP prevents osteoporosis by improving the microstructure of trabecular bone,reducing bone turnover,increasing OPG and reducing RANKL expression.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: The Journal of Practical Medicine Year: 2017 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: The Journal of Practical Medicine Year: 2017 Type: Article