Formula Optimization of Ibuprofen Sustained-release Dropping Pills by Box-Behnken Response-surface Method / 中国药师
China Pharmacist
;
(12): 1012-1016, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-619676
ABSTRACT
Objective:
To prepare ibuprofen sustained-release dropping pills, to evaluate the accumulative release percentage in vitro and to study the drug state in the base.Methods:
With the drug content, mass ratio of water-soluble base to insoluble base and mass ratio of stearic acid to glyceryl monostearate as the investigation factors, and the comprehensive score of 2-hour and 10-hour cumulative dissolution rate as the evaluation index, a Box-Behnken response-surface method was used to screen the optimal formula of ibuprofen sustained-release dropping pills.The drug state in the matrix was examined by differential scanning calorimetry (DSC).Results:
The optimal formula of ibuprofen sustained-release dropping pills was as follows the drug content of 10%, water-soluble and insoluble matrix ratio of 4∶1, and stearic acid and glyceryl monostearate ratio of 3∶1.The maximum cumulative dissolution rate of ibuprofen sustained-release dropping pills was 78.85%.The DSC analysis showed that the drug crystallization peak disappeared in the sustained-release dropping pills, and formed a solid dispersion.Conclusion:
The preparation has good sustained-release effect, and the preparation process is simple.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS