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HPLC Fingerprint study of Ziziphi Spinosae Folium / 药物评价研究
Drug Evaluation Research ; (6): 797-800, 2017.
Article in Chinese | WPRIM | ID: wpr-619694
ABSTRACT
Objective To establish a specific HPLC method and a standard fingerprint for quality control ofZiziphi Spinosae Folium.Methods The samples were separated on a Kinetex C18 column (100 mm × 2.1 mm,2.6 μm) by gradient elution at the flow rate of 300 μL/min using acetonitrile and 0.1% aqueous formic acid as the mobile phase.The column temperature was 30℃.The detection wavelength was 225 nm and the sample size was 10 μL.The fingerprint evaluation software (2012 edition) for Chinese materia medica (CMM) was used to evaluate the similarity of the 12 batches of samples.Results There were 13 characteristic peaks identified in the characteristic spectra ofZiziphi Spinosae Folium samples.Peak 6 was Rutin.The similarities of 13 batches ofZiziphi Spinosae Folium samples were proved to behigher than 0.850.Conclusion The method is available with a good reproducibility and accuraty which can control the quality standards effectively.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Prognostic study Language: Chinese Journal: Drug Evaluation Research Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Prognostic study Language: Chinese Journal: Drug Evaluation Research Year: 2017 Type: Article