Changes of platelet function in Alzheimer-like triple transgenic mice and its mechanism / 中国比较医学杂志
Chinese Journal of Comparative Medicine
;
(6): 17-21, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-619774
ABSTRACT
Objective To investigate the changes of the platelet function in APP/PS-1/tau(3xTg) mice, a murine model for Alzheimer''s disease,and explore its mechanisms.Methods We assessed the change of function of platelet in 3xTg-AD mice by flow cytometry.Adhesion assay and Western blotting were used to compare with the data of wild type mice.Results Platelets from aged 3xTg-AD mice were normal in number and glycoprotein expression (P>0.05), but adhere more avidly on matrices such as fibrinogen, compared with the platelets from age-matching wild type mice (P0.05).Conclusions These results demonstrate that Alzheimer''s mutations result in a significant hyper-activated adhesion state of circulating platelets, evident with the progression of the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Comparative Medicine
Year:
2017
Type:
Article
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