Content Determination of Ketoprofen in Ketoprofen Enteric-coated Capsules by Improving HPLC / 中国药房
China Pharmacy
;
(12): 2579-2581, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-619854
ABSTRACT
OBJECTIVE:
To improve HPLC for content determination of ketoprofen in Ketoprofen enteric-coated capsules.METHODS:
HPLC method was adopted. The determination was performed on Chiralpak IC column with mobile phase consisted of n-hexane (0.1% TFA)-isopropanol(9010,V/V)at a flow rate of 0.8 mL/min. The detection wavelength was set at 268 nm,and column temperature was 25 ℃. The sample size was 10 μL.RESULTS:
The linear range of ketoprofen were 0.025-0.5 mg/mL(r=0.9998). The limit of quantitation was 1.0 mg/L,and limit of detection was 0.2 mg/L. RSDs of precision,stability and reproduc-ibility tests were lower than 2%;recoveries were 96.36%-100.32%(RSD=1.87%,n=6).CONCLUSIONS:
The method is sim-ple,accurate and rapid,and can be used for the content determination of ketoprofen in Ketoprofen enteric-coated capsules.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS