Correlation between microalbuminuria and vascular dementia / 国际脑血管病杂志

ABSTRACT

ObjectiveTo investigate the correlation between microalbuminuria (MA) and vascular dementia (VaD).MethodsThe patients with VaD and the age-and sex-matched controls were enrolled.The urinary albumin/creatinine ratio (UACR) was detected, and MA was defined as UACR 30-300 mg/g.The demographic and clinical data in both groups were compared, and multivariate logistic regression analysis was used to investigate the correlation between MA and VaD.ResultsA total of 45 patients with VaD and 58 inpatient controls without dementia during the same time period were enrolled.There were significant differences in age (82.36±7.68 years vs.78.57±9.46 years;t=-2.183, P=0.031), years of education (10.84±3.59 years vs.13.41±2.03 years;t=4.590, P<0.001), systolic blood pressure (137.11±14.31 mmHg vs.128.57±16.90 mmHg, 1 mmHg=0.133 kPa;t=-2.717, P=0.008), fasting glucose (5.75±1.01 mmol/L vs.5.22±1.25 mmol/L;t=2.344, P=0.021), glycosylated hemoglobin (6.35%±1.10% vs.6.00%±0.66%;t=1.950, P=0.05), and the proportions of hyperlipidemia (64.4% vs.39.7%;χ2=6.229, P=0.013), and positive MA (82.2% vs.25.9%, χ2=32.199, P<0.001) between the VaD group and the control group.Multivariate logistic regression analysis showed that hyperlipidemia (odds ratio [OR] 5.169, 95% confidence interval [CI] 1.243-21.494;P=0.024), fasting glucose (OR 3.090, 95% CI 1.317-7.247;P=0.009), glycosylated hemoglobin (OR 3.951, 95% CI 1.017-8.608;P=0.047) and MA (OR 7.220, 95% CI 1.912-27.266;P=0.004) were all independently correlated with VaD.Conclusions MA was closely associated with the occurrence of VaD.MA, fasting glucose, glycosylated hemoglobin, and hyperlipidemia were the independent risk factors for VaD.