Research Progress on Pancreas Regeneration Gene Reg3 / 医药导报
Herald of Medicine
;
(12): 719-726, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-620264
ABSTRACT
Objective Regenerating genes express mainly in gastrointestinal tissues and the injured regenerating pancreatic tissues,which can promote the regeneration of pancreatic β cells and other tissue cells.In recent years,researches on Reg family mainly involved the gene structure of various subtypes of Reg,and its role in diabetes,gastrointestinal cancer,inflammation,anti-microbial and the related mechanisms.Among the various subtypes of Reg,regenerating geneⅢ(Reg3) plays a particularly crucial role in these diseases.Therefore,Reg3 is a promising target for the treatment of these diseases.Based on the relationships of Reg3 with a variety of diseases,our group devote to the role of Reg3 [human REG3A,and mouse Reg3γ(Reg3g)] in type 1 diabetes,inflammation-linked pancreatic carcinogenesis,and the immunological changes participated in these processes.Hence,this review will summarize serial studies on Reg3 and the feasibility of it as drug targets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Herald of Medicine
Year:
2017
Type:
Article
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