Changes of HMGB1 and GPX3 in thyroid cancer and their relation with pathologic characteristics / 重庆医学

ABSTRACT

Objective To investigate the changes of high mobility group box 1 (HMGB1),glutathione peroxidase(GPX3) in thyroid carcinoma and thier relationship with pathological characteristics.Methods The levels of HMGB1 and GPX3 were detected by using ELISA in 153 cases of thyroid cancer,120 cases of benign thyroid nodules and 120 healthy controls.The changes of HMGB1 and GPX3 in the patients with thyroid cancer were analyzed.Their application value in thyroid cancer was analyzed by using the receiver operating characteristic(ROC) curve.Results The plasma HMGB1 level and the HMGB1 positive expression rate in the thyroid cancer group were higher than those in the benign thyroid nodules group and control group(P＜0.05),while the plasma GPX3 level and GPX3 positive expression rate in the thyroid cancer group were lower than those in the benign thyroid nodules group and control group(P＜0.05).There were no significant differences in the levels of plasma HMGB1,GPX3 and the positive rates of HMGB1 and GPX3 between the thyroid benign nodule group and the healthy control group (P ＞ 0.05).The plasma H MGB1 expression in thyroid cancer was closely related with the infiltration degree,clinical stage and lymph node metastasis(P＜ 0.05),and the GPX3 expression was related with the tumor stage and lymph node metastasis(P＜0.05).The ROC curve showed that the sensitivity and specificity of HMGB1 and GPX3 for diagnosing thyroid cancer were 76.3％ and 85.5％,70.8％ and 82.2％ respectively.Conclusion Plasma HMGB1 and GPX3 expression levels are closely associated with the occurrence and progression of thyroid cancer.