Roles of Opioid Receptor Subtype in the Spinal Antinociception of Selective Cyclooxygenase 2 Inhibitor
The Korean Journal of Pain
;
: 236-241, 2010.
Article
in English
| WPRIM
| ID: wpr-62033
ABSTRACT
BACKGROUND:
Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis, evidences suggesting endogenous opioid peptide link in spinal antinociception of COX inhibitor have been reported. We investigated the roles of opioid receptor subtypes in the spinal antinociception of selective COX-2 inhibitor.METHODS:
To examine the antinociception of a selective COX-2 inhibitor, DUP-697 was delivered through an intrathecal catheter, 10 minutes before the formalin test in male Sprague-Dawley rats. Then, the effect of intrathecal pretreatment with CTOP, naltrindole and GNTI, which are micro, delta and kappa opioid receptor antagonist, respectively, on the analgesia induced by DUP-697 was assessed.RESULTS:
Intrathecal DUP-697 reduced the flinching response evoked by formalin injection during phase 1 and 2. Naltrindole and GNTI attenuated the antinociceptive effect of intrathecal DUP-697 during both phases of the formalin test. CTOP reversed the antinociception of DUP-697 during phase 2, but not during phase 1.CONCLUSIONS:
Intrathecal DUP-697, a selective COX-2 inhibitor, effectively relieved inflammatory pain in rats. The delta and kappa opioid receptors are involved in the activity of COX-2 inhibitor on the facilitated state as well as acute pain at the spinal level, whereas the micro opioid receptor is related only to facilitated pain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thiophenes
/
Pain Measurement
/
Somatostatin
/
Carbonates
/
Prostaglandin-Endoperoxide Synthases
/
Rats, Sprague-Dawley
/
Receptors, Opioid
/
Receptors, Opioid, kappa
/
Opioid Peptides
/
Cyclooxygenase 2
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
The Korean Journal of Pain
Year:
2010
Type:
Article
Similar
MEDLINE
...
LILACS
LIS