Effect of calcipotriol on psoriasis and its effect of peripheral blood IFN-γ, IL-2 and IL-4 levels / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of calcipotriol on psoriasis and its effect of peripheral blood interleukin-2(IL-2), interferon-γ(IFN-γ), IL-4 and IL-10 and the percent of cell TH17.Methods From March 2013 to June 2016, 96 patients with psoriasis vulgaris inour hospital were randomly divided into control group and study group according to different treatment regimens, each group 48 cases.The control group was treated with YujinXiaoyin Decoction, and the study group was treated with YujinXiaoyin Decoction and calcipotriolointment,both groups were treated for 3 months.Treatment effect, psoriasis lesion area and severity index(PASI) score, the incidence of adverse reactions were statistically analyzed of the two groups,and the levels of IL-10, IL-2, IFN-γ, IL-4 and peripheral blood TH17 cells percentagewere measured and compared.Results The treatment effectafter treatmentfor 1month, 2 months and 3 months of the study group were significantly higher than those of the control group, but PASI score was lower than the control group, the difference was statistically significant(P<0.05);The peripheral blood IL-10, IL-2, IFN-γ and IL-4 levels after treatment for 3 months in the study group were significantly lower than those before treatment, and was significantly lower than that of the control group(P<0.05);The percentage of TH17 cells in the two groups after treatment for 3 months was significantly lower than before treatment, and the study group was significantly lower than that of the control group(P<0.05);The incidence of adverse events in the study group(4.17%) was lower than that in the control group(18.75%) after treatment, the difference was statistically significant(P<0.05).Conclusion The efficacy of carbapenol in the treatment of psoriasis is significant, which can effectively improve the skin lesions and reduce the the peripheral blood IL-10, IL-2, IFN-γ, IL-4levels and the safety is high.