Evaluation of the effect of contrast-enhanced ultrasonography onradiofrequency ablation combined with absolute alcohol injection in hepatocellular carcinoma / 中国生化药物杂志

ABSTRACT

Objective To evaluate the efficacy of radiofrequency ablation combined with absolute ethanol injection in the treatment of hepatocellular carcinoma (HCC), and to study the value of contrast-enhanced ultrasound in the evaluation of therapeutic effect.Methods From May 2015 to May 2017, 60 patients with liver cancer (72 lesions) were treated in our hospital.The patients were divided into 3 groups, the RFA treatment group (n=20), 24 lesions, the PEI treatment group (n=20), 22 lesions, and the RFA+PEI treatment group (n=20) with26 lesions.3 groups of patients were treated with contrast-enhanced ultrasound (CEUS), routine color Doppler ultrasound (CDUS), enhanced CT to evaluate the specific situation of the tumor, and evaluate the therapeutic effect again after operation.The rates of necrosis, lesion inactivation and residue were evaluated in each group.Results The necrosis rate of RFA group, PEI group and RFA+PEI group were66.67%,81.82% and 96.15%, respectively.The necrosis rate of CT group was the highest, and the difference was statistically significant (P<0.05) in RFA+PEI group.Comparison of different imaging to assess the sensitivity and specificity of CDUS, to evaluate the sensitivity and specificity were 81.36% and 53.85%;CEUS to evaluate the sensitivity and specificity were 98.31% and 84.62%, significant difference was statistically significant (P<0.05).Conclusion RFA+PEI treatment program is better than RFA and PEI alone treatment, the treatment effect is better, CEUS in the evaluation of RFA+PEI treatment effect, has higher clinical value.