Study on the effect of dinoprostone, misoprostol and oxytocin on the treatment of cervical ripening and labor induction / 中国生化药物杂志

ABSTRACT

Objective To compare and analyze the effect of dinoprostone misoprostol and oxytocin in cervical ripening and labor induction.Methods 120 pregnant women in labor in our hospital from January 2015 to January 2017 were selected as the object in this study, all pregnant women were randomly divided into 3 groups, respectively dinoprostone group, misoprostol group and oxytocin group, 40 pregnant in each group., Dinoprostone was placed in vaginal fornix in dinoprostone group;misoprostol was placed in vaginal fornix in misoprostol group;Oxytocin was injected in oxytocin group.The delivery time, rupture time of fetal membranes, labor time and successful rate of induced labor in the 3 groups were compared.Results The dinoprostone group after treatment in pregnant women take delivery time,time and labor rupture time were significantly shorter than the other two groups(P<0.05),the difference was statistically significant;dinoprostone group of pregnant women, the success rate was significantly higher than that of oxytocin group, compared between the two groups(P<0.05),with statistical significance difference;dinoprostone group did not appear abnormal, less adverse reaction.Conclusion Dinoprostone used for cervical ripening and labor induction, the effect is significant, compared with misoprostol and oxytocin, less adverse reaction, high safety, and is worthy of popularization and application.