Effects of breviscapine combined with aspirin on aspirin resistance in elderly patients with coronary heart disease / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of breviscapine combined with aspirin on aspirin resistance and clinical effect in elderly patients with coronary heart disease.Methods A total of 178 patients with angina pectoris treated in our hospital from January 2014 to December 2015 were randomly divided into two groups,with 89 cases in each group.The control group received 100 mg oral administration of aspirin.The study group was given breviscapine tablets oral on the basis of the control group.After six months of treatment, aspirin resistance, hemorheology, serum lipid peroxides(LPO), superoxide dismutase(SOD), homocysteine(Hcy), hypersensitivity C-reactive protein(hs-CRP) and interleukin-6(IL-6) were measured.The incidence of clinical efficacy and end points was statistically analyzed.Results The rates of aspirin resistance, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte aggregation index, fibrinogen, LPO, Hcy, hs-CRP, IL-6 levels and end point events in the study group were lower than the control group(P<0.05).The level of SOD and the clinical efficiency were higher than those of the control group(P<0.05).Conclusion Breviscapine combined with aspirin in the treatment of senile coronary heart disease can reduce aspirin resistance, improve clinical effect, reduce the incidence of end points, with clinical value.