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Altered Regulation of 11beta-hydroxysteroid Dehydrogenase II in the Kidney of Rats with Experimental Hypertension
Article in En | WPRIM | ID: wpr-62075
Responsible library: WPRO
ABSTRACT
The present study was aimed at investigating the role of type II 11beta-hydroxysteroid dehydrogenase (IIbeta- HSD II) in the development of hypertension. Two-kidney, one-clip (2K1C), deoxycorticosterone acetate (DOCA)/salt, or NG-nitro-L-arginine methyl ester (L-NAME) hypertension was induced in male Sprague- Dawley rats. Four weeks later, the expression of 11beta-HSD II mRNA was determined in the kidney by Northern blot analysis. The plasma level of aldosterone was measured by radioimmunoassay. In 2K1C hypertension, the expression of 11beta-HSD II was decreased in the clipped kidney and increased in the non-clipped kidney. The expression was increased in the remnant kidney of DOCA/salt hypertension, while decreased in the kidneys of L-NAME hypertension. The plasma level of aldosterone was increased, decreased, and remained unchanged in 2K1C, DOCA/salt, and L-NAME hypertension, respectively. The down-regulation of 11beta-HSD II may contribute to the sodium retention, thereby increasing the blood pressure in 2K1C and L-NAME hypertension. On the contrary, the up-regulation in DOCA/salt hypertension may play a compensatory role to dissipate the sodium retention.
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Full text: 1 Index: WPRIM Main subject: Plasma / Sodium / Blood Pressure / RNA, Messenger / Radioimmunoassay / Down-Regulation / Up-Regulation / Blotting, Northern / NG-Nitroarginine Methyl Ester / 11-beta-Hydroxysteroid Dehydrogenases Limits: Animals / Humans / Male Language: En Journal: Electrolytes & Blood Pressure Year: 2007 Type: Article
Full text: 1 Index: WPRIM Main subject: Plasma / Sodium / Blood Pressure / RNA, Messenger / Radioimmunoassay / Down-Regulation / Up-Regulation / Blotting, Northern / NG-Nitroarginine Methyl Ester / 11-beta-Hydroxysteroid Dehydrogenases Limits: Animals / Humans / Male Language: En Journal: Electrolytes & Blood Pressure Year: 2007 Type: Article