Correlation between peak intensity of contrast enhanced ultrasound and injury severity after liver ischemia reperfusion / 中华器官移植杂志

ABSTRACT

Objective To discuss the correlation between peak intensity (PI) of contrast enhanced ultrasound and injury severity after liver ischemia reperfusion.Methods Pringle's maneuver was used to establish the liver 15-min ischemia model.Contrast enhanced ultrasound was used to observe the hepatic perfusion after reperfusion of 1 h,6 h and 24 h,and the PI was recorded.The correlation analysis on PI with alanine aminotransferase (ALT),aspartate aminotransferase (AST) and pathologic changes (Suzuki standard) was done.Results PI decreased after 1 h,6 h,and 24 h of liver reperfusion,most significantly at 6 h.ALT reached the peak after 1 h of reperfusion and then decreased after 6 h and 24 h.AST increased after 6 h of reperfusion and decreased after 24 h.After 1 h of reperfusion,mild injury appeared in pathology and the injury became severe after 6 h,then it got moderate-to-severe after 24 h of reperfusion.PI was negatively correlated to ALT,AST and pathologic injury degree.Conclusion The PI relates to the degree of hepatic injury after liver ischemia/reperfusion.The more severe the injury is,the lower the PI.