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Effect of aerobics exercise on myocardial fibrosis after acute myocardial infarction in rat / 中国医师杂志
Journal of Chinese Physician ; (12): 852-854, 2017.
Article in Zh | WPRIM | ID: wpr-621013
Responsible library: WPRO
ABSTRACT
Objective To observe the effect of aerobics exercise on myocardial fibrosis after acute myocardial infarction (AMI) in rat.Methods Twenty-four AMI Sprague Dawley (SD) rats were randomly assigned to sham-operated group (Sham),AMI group and aerobics exercise treatment group (ET).Except Sham,other groups of rats were underwent anterior wall myocardial infarction.After ten weeks,the myocardial mRNA level of connective tissue growth factor (CTGF),collagen Ⅰ (COL1 a1),collagen Ⅲ (COL3a1) detected by real time-quantitative polymerase chain reaction (PCR) analysis and myocardial collagen volume fraction (CVF) was determined on Masson stained sections.Results Campared to Sham-operated group,AMI group the level of CTGF,COL1a1,COL3a1,and CVF were increased (P <0.05,P < 0.01).Campared to AMI and ET groups,the levels of CTGF,COL1a1,COL3a1,and CVF were decreased (P < 0.05,P < 0.01).Conclusions Aerobics exercise can reduced the myocardial fibrosis after AMI in rat.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Chinese Physician Year: 2017 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Chinese Physician Year: 2017 Type: Article