Clinical Observation of Acupuncture plus Medication for Vascular Dementia Due to Blood Stasis Blocking Collaterals / 上海针灸杂志

ABSTRACT

Objective To observe the clinical efficacy of acupuncture plus Nao Xue Shu oral liquid in treating vascular dementia (VD) due to blood stasis blocking collaterals. Method A total of 135 patients with VD due to blood stasis blocking collaterals were randomized into a basic group, a medication group, and an acupuncture-medication group, 45 cases in each group. The basic group was intervened by conventional treatment, while the control group was additionally given Nao Xue Shu oral liquid, and the acupuncture-medication group was additionally intervened by acupuncture plus Nao Xue Shu oral liquid, 60 d as a treatment course. The Mini-mental State Examination (MMSE), Brief Screening Scale for Dementia (BSSD) and the syndrome of blood stasis blocking collaterals subscale in the syndrome differentiation scale of vascular dementia (SDSVDA) were scored before and after the treatment, and the changes of calcitonin gene-related peptide (CGRP), lipid peroxidation (LPO) and serum uric acid (SUA) were also observed. Result One case dropped out in the basic group. After 60-day treatment, the total effective rate was 91.1%(41/45) in the acupuncture-medication group, significantly higher than 65.9% (29/44) in the basic group (P<0.01) and 75.6% (34/45) in the medication group (P<0.05). The improvements of MMSE, BSSD and SDSVDA scores in the acupuncture-medication group were more significant than those in the basic group and medication group (P<0.05). The improvements of CGRP, LPO and SUA levels in the acupuncture-medication group were superior to those in the basic group and medication group (P<0.05). Conclusion Traditional acupuncture method plus Nao Xue Shu oral liquid can produce a significant efficacy in treating VD due to blood stasis blocking collaterals.