Scientific rationale and applicability of dose-reponse models for environmental carcinogens / 예방의학회지
Korean Journal of Preventive Medicine
;
: 27-42, 1996.
Article
in Korean
| WPRIM
| ID: wpr-62135
ABSTRACT
This study described methods to predict human health risk associated with exposure to environmental carciongens using animal bioassay data. Also, biological assumption for various dose-response models were reviewed. To illustrate the process of risk estimate using relevant dose-response models such as Log-normal, Mantel-Bryan, Weibull and Multistage model, we used four animal carcinogenesis bioassy data of chloroform and chloroform concentrations of tap water measured in large cities of korea from 1987 to 1995. As a result, in the case of using average concentration in exposure data and 95 % upper boud unit risk of Multistage model, excess cancer risk(RISK I) was about 1.9 x 10-6, in the case of using probability distribution of cumulative exposure data and unit risks, those risks(RISK II) which were simulated by Monte-Carlo analysis were about 2.4 x 10(-6) and 7.9 x 10(-5) at 50 and 95 percentile, respectively. Therefore risk estimated by Monte-Carlo analysis using probability distribution of input variables may be more conservative.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biological Assay
/
Water
/
Carcinogens, Environmental
/
Chloroform
/
Carcinogenesis
/
Korea
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Preventive Medicine
Year:
1996
Type:
Article
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