Efficacy of Shaaban and low molecular weight heparin in prevention and treatment of deep venous thrombosis after knee replacement / 中国生化药物杂志

ABSTRACT

Objective To compare the efficacy of Shaaban and low molecular weight heparin in the prevention and treatment of deep venous thrombosis of lower extremity after knee replacement. Methods January 2011 to 2013 year in January in our hospital 120 cases of knee joint replacement patients as the research object, divided into observation group and control group, the observation group were treated by oral anticoagulant treatment of Lee Shaaban, the control group by subcutaneous injection of low molecular weight heparin treatment than patients were compared between the two groups after deep vein thrombosis the incidence of 14d after treatment, adverse reactions and blood coagulation indexes in patients with drug. Results The observation group of patients with deep vein thrombosis rate was 1.67%, significantly lower than the control group 13.34%, the difference was statistically significant (P<0.05); no statistical significance in two groups of patients after the treatment of 14d PLT, APTT and PT level difference; the observation group of patients with drug adverse reaction incidence rate was 5%. The 13.34% was significantly lower than the control group, the difference was statistically significant (P<0.05). Conclusion Compared with low molecular weight heparin, the incidence of deep vein thrombosis is lower, the adverse reactions are less, and the curative effect is more obvious after applying Shaaban's knee replacement.