Effects of different doses of dexmedetomidine combined with propofol and remifentanil on anesthesia in patients undergoing abdominal surgery / 中国生化药物杂志

ABSTRACT

Objective To study the effect of different doses of dexmedetomidine combined with propofol and remifentanil in patients undergoing abdominal surgery. Methods 200 cases of abdominal operation in our hospital from January 2015 to August 2016 were selected as the subjects, and were randomly divided into the experimental group and the control group, with 100 patients in each group. Patients in the control group received 0.4μg/kg, dexmedetomidine hydrochloride injection combined with propofol and remifentanil anesthesia, and the experimental group received 0.8μg/kg, Dexmedetomidine Hydrochloride Injection anesthesia. The adverse reactions, extubation time and recovery time of the experimental group and the control group were compared and analyzed. Results After the corresponding dose of dexmedetomidine, the patients in the experimental group were 6 cases of nausea and vomiting, 7 patients with chills, 13 cases of adverse reactions, the total incidence was 13%. In the control group, shivering occurred in 23 cases, nausea and vomiting occurred in 12 patients, and the number of adverse reactions in 35 cases, the incidence of adverse reactions was 35%. The probability of adverse reactions in the control group was significantly higher than that in the control group, with statistical difference (P<0.05). The recovery time and extubation time of the experimental group were significantly lower than those of the control group, with statistical difference (P<0.05). Conclusion 0.8μg / kg dexmedetomidine hydrochloride Iinjection combined with propofol and remifentanil anesthesia in abdominal surgery is better anesthesia effect, can significantly shorten the time of patients with tube drawing, high safety, reduce the pain and risk of surgery patients has clinical significance in the further promotion and application.