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Flow-injection-enhanced chemiluminescence method for the determination of three β-blockers / 药物分析学报
Article in Zh | WPRIM | ID: wpr-621623
Responsible library: WPRO
ABSTRACT
Objective To develop a rapid, simple and sensitive chemiluminescence method for the determination of three β-blockers (bisoprolol, atenolol and propranolol). Methods The chemiluminescence of cerium (Ⅳ)-sulfite system was obviously sensitized by adding anyone of three β-blockers in acid media. A new chemiluminescence method was set up by combining with flow-injection technique and used to determine the three β-blockers. Results Good linear ranges were obtained at the concentrations of 2.0×10-7g/mL-4.0×10-5g/mL, 1.0×10-7g/mL-3.0×10-5g/mL and 7.0×10-7g/mL-1.0×10-5g/mL, respectively, with the detection limits of 5.0×10-8g/mL, 7.0×10-8g/mL and 5.0×10-8g/mL (S/N=3), respectively, and the relative standard deviations for 11 times consecutive injections of 1.0×10-6g/mL bisoprolol, atenolol and propranolol were 3.57%, 2.21% and 2.26%, respectively. Conclusion The developed method is sensitive, accurate, rapid and of low cost. And it can be applied to determine bisoprolol, atenolol and propranolol in pharmaceutical preparations.
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Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Pharmaceutical Analysis Year: 2010 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Journal of Pharmaceutical Analysis Year: 2010 Type: Article