THE ROLE OF BRAIN-STEM DISCENDING INHIBITORY SYSTEM IN THE ANTINOCICEPTIVE EFFECT ELICITED BY MUSCLE SPINDLE AFFERENTS / 药物分析学报

ABSTRACT

Objective To analyse the antinociceptive effect of muscle spindle afferents and the involved mechanism.Methods The single unit of wide dynamic range(WDR) neurons in the spinal cord dorsal horn were recorded extracelluarly.The effects of muscle spindle afferents elicited by intravenous administration of succinylcholine (Sch) on nociceptive responses (C-fibres-evoked responses,C-responses) of WDR neurons were observed before and after bilateral lesions of ventrolateral periaqueduct gray (PAG).And the effects of muscle spindle afferents on the spontaneous discharge of the tail-flick related cell in the rostral ventro medial medulla (RVM) and on the spontaneous discharge of the PAG neurons were observed.Results The C-responses of WDR neurons were significantly inhibited by muscle spindle afferents,and the inhibitory effects were reduced by bilateral lesions of ventrolateral PAG.The spontaneous discharge of the off-cell in the RVM was excited while the on-cell was inhibited by intravenous administration of Sch.The spontaneous discharge of the PAG neurons were excited by muscle spindle afferents.Conclusion Muscle spindle afferents show a distinct effect of antinociception.PAG-RVM descending inhibitory system may play an important role in this nociceptive modulative mechanism.