Effect of Diane-35 and metformin on blood-adipose and sex hormone in patients with polycystic ovary syndrome / 中华内分泌外科杂志

ABSTRACT

Objective To investigate the effect of Diane-35 and metformin on blood-adipose and sex hor-mone in patients with polycystic ovary syndrome ( PCOS ) .Methods 52 cases with PCOS admitted from Jan . 2010 to Jan.2013 were selected as research objects .They were randomly divided into the control group and the observation group .The control group were treated with metformin , while the observation group with metformin and Diane-35.Follicle-stimulating hormone ( FSH), luteinizing hormone ( LH), testosterone ( T), total cholesterol (TC), triglyceride(TG), high density lipoprotein(HDL), low-density lipoprotein(LDL)in the 2 groups of pa-tients were tested before and after treatment .Results The levels of blood-adipose and sex hormone between the 2 groups had no statistical difference (P>0.05).The level of T reduced in the control group after treatment , and there was statistical difference compared with that before treatment ( P <0.05 ) .FSH and LH levels did not change obviously in the observation group .Levels of LH and T in the observation group reduced , and had statisti-cal difference with that before treatment (P<0.05).FSH levels did not change significantly after treatment .Lev-els of LH and T had statistical difference between the 2 groups(P<0.05).Levels of TC, TG, and LDL reduced after treatment and had statistical difference compared with those before treatment ( P<0.05 ) while HDL signifi-cantly increased after treatment(P<0.05).Levels of TC, TG, HDL, and LDL between the 2 groups were signif-icantly different(P<0.05).Conclusion Metformin combined with Diane-35 are effective in improving the lev-els of blood-adipose and sex hormone in patients with PCOS .