Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
Blood Research
;
: 106-111, 2017.
Article
in English
| WPRIM
| ID: wpr-62220
ABSTRACT
BACKGROUND:
Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL.METHODS:
Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR.RESULTS:
Significant differences in the mean expression levels of TAX and HBZ were observed between the two study groups (ATLL and AC, P=0.014 and P=0.000, respectively). In addition, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P=0.047).CONCLUSION:
The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prognosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Prognosis
/
Taxes
/
RNA, Messenger
/
T-Lymphocytes
/
Biomarkers
/
Human T-lymphotropic virus 1
/
Leukemia-Lymphoma, Adult T-Cell
/
Trans-Activators
/
Polymerase Chain Reaction
Type of study:
Prognostic study
Limits:
Adult
/
Humans
Language:
English
Journal:
Blood Research
Year:
2017
Type:
Article
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