Long-term outcome and tolerability of ketogenic diet treatment for refractory epilepsies in children –A tertiary centre Malaysian experience
Neurology Asia
;
: 17-21, 2016.
Article
in English
| WPRIM
| ID: wpr-625211
ABSTRACT
Objective:
To evaluate the long-term efficacy, retention rate and tolerability of ketogenic diet treatment (KD) for children with medically refractory epilepsies from a single tertiary centre in Malaysia.Methods:
Children who were treated with ketogenic diet since 2006 and had at least 2 years follow up after initiation of the KD were evaluated retrospectively using intention-to-treat principle. Response is defined at seizure reduction of > 50%. Efficacy was assessed as percentage of patients who had seizure reduction by >50%, >90% and seizure freedom and retention rate was the proportion of patients who remained on ketogenic diet.Result:
A total of thirty children were included. The median duration of treatment was 8 months (range 7 days to 6 years). Retention rates at 3, 6, 12 and 24 months were 80%, 70%, 50% and 40% and responder rates were 70%, 63%, 47% and 37% respectively. The common adverse effects were constipation (43%), hunger (23%), excessive weight gain or loss (20%), vomiting (10%), hyperuricaemia(30%), hypocalcaemia (20%) and renal calculi (13%). The common reasons for stopping were because the diet was too restrictive (33%), infrequent seizure or seizure freedom (23%), not effective (17%) but none was due to the adverse effects.Conclusion:
Ketogenic diet treatment is effective and well-tolerated by Malaysian children in general.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Epilepsy
/
Diet, Ketogenic
Language:
English
Journal:
Neurology Asia
Year:
2016
Type:
Article
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