Acute encephalopathy in Dravet syndrome: Case reports and literature review
Neurology Asia
;
: 181-185, 2016.
Article
in English
| WPRIM
| ID: wpr-625251
ABSTRACT
Dravet syndrome is a rare and catastrophic type of epilepsy in infants. Acute encephalopathy has been sporadically reported in patients with Dravet syndrome; however, the risk factors for this serious complication have not been identified. We report two patients with a clinical diagnosis of Dravet syndrome who experienced acute encephalopathy initiated by refractory status epilepticus. SCN1A mutational analysis revealed a previously reported nonsense mutation in one patient and a novel missense mutation in the other. Analysis of our cases and previously published cases revealed that patients with Dravet syndrome who have a more severe phenotype have an increased likelihood of developing acute encephalopathy compared with patients with less severe phenotypes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Epilepsies, Myoclonic
Type of study:
Prognostic study
/
Risk factors
Language:
English
Journal:
Neurology Asia
Year:
2016
Type:
Article
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