Thrombocytopenia With Valproate And Clozapine Combination Therapy
ASEAN Journal of Psychiatry
;
: 1-4, 2011.
Article
in English
| WPRIM
| ID: wpr-625597
ABSTRACT
Objective:
The occurrence of thrombocytopenia with valproate and clozapine combination therapy has not been noted in the literature. This case report highlights thrombocytopenia as a potential outcome of drug-drug interaction between valproate and clozapine, and serves to remind practitioners that regular monitoring of platelet counts is necessary in such combination therapy.Method:
We report on a patient on valproate therapy who developed thrombocytopenia when clozapine was added to her treatment regime.Results:
Thrombocytopenia resolved 1 week after valproate was tailed off and the patient was placed on clozapine monotherapy.Conclusions:
A precise pathophysiologic understanding of valproate and clozapine-induced thrombocytopenia is lacking, and further studies are required.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
ASEAN Journal of Psychiatry
Year:
2011
Type:
Article
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