Analysing result of cytogenetic tests in 24 patients with hypospadias in comparison with clinical and surgical diagnosis

ABSTRACT

Analysing cytogenetic charateristics of 24 patients with hypospadias in Vietnam National Hospital of Pediatrics from January to December 1998, comparing with clinical and surgical diagnosis. 3 children were found with chromosomal aberrations. All these children had peripheral hypospadias , 2 out of 3 children had bilateral undescend testes, 1 child had unilateral undescend testes. Chromosomal test found that 1 child had mosaicism 46,XX(90%)/47XXY(10%); Barr bodies 8%, 2 children had 46,XX males, 1 out of these 2 children had plastic surgery for male urethra. The results of Barr bodies tests were corresponded to karyotypes. If karyotype is 46,XY, Barr bodies tests are negative; if karyotype is 46,XX, Barr bodies tests are positive