A Case of Histoid Leproma with Mycobacterium leprae Detected in the Peripheral Blood by polymerase Chain Reaction / 대한피부과학회지
Korean Journal of Dermatology
;
: 167-171, 1994.
Article
in Korean
| WPRIM
| ID: wpr-62638
ABSTRACT
Histoid leproma usually occur in pat.ients with lepromatous leproy who have had relapsed after being undcr treatment(usually sulfones) for a long time and who have shown variable improvement. A 56 year old female patient who had been suffering from lepromatous leprosy and had been treated which clapsone relatively regularly for approximately 28 years had a history of several shiny rice grain t.o peanut sized nodules on the face and right flank. Histopathologic examination of a specimen taken from a nodular lesian revealed a well circirmscrihed nodule composed mainly of spindle-shaped cells and epitheioi 1 cells on the upper and mid-levmis, and granuloma composed of epithelioid cells, multinucleated wait cells and foamy histiocytes on the lower dermis. In AFB stain, numerous acid-fast bacilli were scatt red dermis and epidermis, especially stratum corneum. This study opplied a polymease chain reaction(PCR) on sections of biopsy tissues and peripheral blood of pat.ient. Positive amplification of a 530 bp fragment was deteated not only in the lesion tissues but also in the per ipher al blood.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Leprosy, Lepromatous
/
Epithelioid Cells
/
Edible Grain
/
Polymerase Chain Reaction
/
Dermis
/
Epidermis
/
Granuloma
/
Histiocytes
/
Mycobacterium
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1994
Type:
Article
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