Medical Treatment of Pulmonary Multidrug-Resistant Tuberculosis / 감염과화학요법
Infection and Chemotherapy
;
: 367-374, 2013.
Article
in English
| WPRIM
| ID: wpr-62693
ABSTRACT
Treatment of multidrug-resistant tuberculosis (MDR-TB) is challenging because of the high toxicity of second-line drugs and the longer treatment duration required compared with drug-susceptible TB. The efficacy of treatment for MDR-TB is poorer than that for drug-susceptible TB. The selection of drugs in MDR-TB is based on previous treatment history, drug susceptibility results, and TB drug resistance patterns in the each region. Recent World Health Organization guidelines recommend the use of least 4 second-line drugs (a newer fluoroquinolone, an injectable agent, prothionamide, and cycloserine or para-aminosalicylic acid) in addition to pyrazinamide. The kanamycin is the initial choice of injectable durgs, and newer fluoroquinolones include levofloxacin and moxifloxacin. For MDR-TB, especially cases that are extensively drug-resistant, group 5 drugs such as linezolid, clofazimine, and amoxicillin/clavulanate need to be included. New agents with novel mechanisms of action that can be given for shorter durations (9-12 months) for MDR-TB are under investigation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prothionamide
/
Pyrazinamide
/
Tuberculosis
/
World Health Organization
/
Drug Resistance
/
Kanamycin
/
Clofazimine
/
Tuberculosis, Multidrug-Resistant
/
Cycloserine
/
Fluoroquinolones
Type of study:
Practice guideline
Language:
English
Journal:
Infection and Chemotherapy
Year:
2013
Type:
Article
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