Effects of Methysergide on Serum Growth Hormone Response after Electroconvulsive Therapy / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 113-117, 1997.
Article
in Korean
| WPRIM
| ID: wpr-62702
ABSTRACT
OBJECTIVES:
The purpose of this study was to investigate the effects of methysergide(serotonin receptor antagonist) on serum growth hormone response after electroconvulsive therapy(ECT).METHODS:
We studied the changes of the serum growth hormone levels of the day before ECT(No ECT), ECT without methysergide pretreatment(ECT alone), and ECT with methysergide pretreatment(M+ECT) by radioimmunoassay method in 14 psychiatric patients. ECT was induced by the application of 110 volts for a period 0.3-1.0 second, using bitemporal electrodes.RESULTS:
1) Serum growth hormone levels at 15, 30, and 60 minutes after ECT were significantly increased in the ECT alone group than in the No ECT group(p<0.05). 2) Serum growth hormone levels at 15, 30, and 60 minites after ECT were significantly decreased in the M+ECT group than in the ECT alone group(p<0.05).CONCLUSION:
These results suggest that the response of growth hormone after ECT seems to be mediated by the activation of serotonergic system.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radioimmunoassay
/
Growth Hormone
/
Electroconvulsive Therapy
/
Electrodes
/
Methysergide
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
1997
Type:
Article
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