Relationship between Therapeutic Response and Plasma HVA/5-HIAA Ratio in Newly Admitted Schizophrenia / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 101-106, 1997.
Article
in Korean
| WPRIM
| ID: wpr-62704
ABSTRACT
Twenty newly admitted acute schizophrenic patients were treated with haloperidol for 6 weeks. HVA and 5-HIAA were sampled at baseline, 3days after initial neuroleptic dose, and after 1, 2, 3, 4, 6 weeks of treatment. Nine patients were classified as responders in this prospective haloperidol treatment trial. They had a score of change in the BPRS total scores of 25% or greater. Eleven patients were classified as nonresponders, based on a score of changes in the BPRS total scores of less than 25%. 1) There was no significant difference in plasma HVA/5-HIAA ratio between responder and non-responder before and after haloperidol treatment. 2) There was no significant correlations between plasma HVA/5-HIAA ratio and BPRS total scores. This study could not support the hypothesis that neuroleptic treatment would be effective by changing dopamine and serotonin function and/or by altering their interaction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Schizophrenia
/
Dopamine
/
Serotonin
/
Prospective Studies
/
Haloperidol
/
Hydroxyindoleacetic Acid
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
1997
Type:
Article
Similar
MEDLINE
...
LILACS
LIS