A Brief Review on Free Light Chain Assays: From Conventional to Current
Malaysian Journal of Medicine and Health Sciences
;
: 59-62, 2017.
Article
in English
| WPRIM
| ID: wpr-627153
ABSTRACT
Free light chains (FLCs) are tumour markers of monoclonal gammopathies. Detection of urinary FLC or also known as Bence-Jones protein through urinary protein and its immunofixation electrophoreses (UPE and uIFE, respectively) have been considered the gold standard for its biochemical diagnosis. This is mainly due to their superior detection limits compared to their counterpart investigations in serum. However, urinalysis is limited in many ways. The emergence of serum FLC assay with markedly improved detection limit circumvents many of these problems and has gained much importance in biochemical investigations of monoclonal gammopathies. Nevertheless, they are not without limitations. This review discusses the advantages and limitations of serum and urinary FLC assays.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Malaysian Journal of Medicine and Health Sciences
Year:
2017
Type:
Article
Similar
MEDLINE
...
LILACS
LIS