Neurodevelopmental Outcome of Newborns with Persistent Pulmonary Hypertension
Malaysian Journal of Medical Sciences
;
: 58-62, 2011.
Article
in English
| WPRIM
| ID: wpr-627941
ABSTRACT
Background:
Developmental disabilities have been reported in infants with persistent pulmonary hypertension of the newborn (PPHN) treated with inhaled nitric oxide (INO) or intravenous magnesium sulphate (MgSO4) and/or extracorporeal membrane oxygenation. This paper reports the rate of developmental disabilities at 2 years of age in a cohort of survivors of PPHN treated with INO, MgSO4, or both during the neonatal period.Methods:
Sixteen survivors of PPHN were prospectively followed up. These infants were treated with intravenous MgSO4 and/or INO during the neonatal period. Neurodevelopmental assessment was carried out at 2 years of age using the Bayley Scales of Infant Development 2nd Edition by a developmental psychologist. Eleven (68.8%) infants completed the 2-year follow-up.Results:
The median mental developmental index (MDI) and physical developmental index scores were 85 (interquartile range, IQR = 27) and 87 (IQR = 33), respectively. Two infants (18.2%) had developmental disability (MDI scores <70).Conclusion:
Survivors of PPHN are at risk of developmental disabilities. Early intervention programme and long-term follow-up should be integrated in the management of these infants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Malaysian Journal of Medical Sciences
Year:
2011
Type:
Article
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