Evaluation of the Antidiabetic and Antilipaemic Activities of the Hydroalcoholic Extract of Phoenix Dactylifera Palm Leaves and Its Fractions in Alloxan-Induced Diabetic Rats
Malaysian Journal of Medical Sciences
;
: 4-13, 2010.
Article
in English
| WPRIM
| ID: wpr-628011
ABSTRACT
Background:
The antidiabetic and antilipaemic effects of Phoenix dactylifera leaf extract (PDE) and its fractions were investigated in various rat models.Methods:
Diabetes was induced in male Wistar rats by alloxan monohydrate. Diabetic animals were randomly divided into 8 groups (1 diabetic control and 7 treated groups). Diabetic control animals received saline (5 mL/kg) orally, whereas the treatment groups received different doses of PDE (100, 200, and 400 mg/kg), PDE fractions (50, 100, and 200 mg/kg), or glibenclamide (4 mg/kg) orally once a day for 14 days. Blood was withdrawn for glucose determination on the 1st, 6th, 10th, and 14th days. The rats were fasted overnight and then sacrificed on the 14th day; blood was collected for biochemical evaluation, including the levels of blood glucose, plasma insulin, serum triglyceride, and cholesterol.Results:
Subacute administration of PDE or its fractions in alloxan-induced diabetic rats significantly reduced blood glucose (P < 0.01). Water intake, serum triglyceride, and cholesterol also decreased in treated animals compared with the control group (P < 0.01). Plasma insulin level increased in the treated groups relative to the control group (P < 0.01).Conclusion:
The results suggested that PDE exhibits antidiabetic and antilipaemic effects in alloxan-induced diabetic rats.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Malaysian Journal of Medical Sciences
Year:
2010
Type:
Article
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