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No association between endothelin-1 gene polymorphisms and preeclampsia in Korean population
Journal of Genetic Medicine ; : 34-40, 2008.
Article in English | WPRIM | ID: wpr-62803
ABSTRACT

PURPOSE:

Preeclampsia is a major cause of maternal and perinatal mortality and morbidity and is considered to be a multifactorial disorder involving a genetic predisposition and environmental factors. Endothelin-1 (ET-1) is a potent vasoconstrictor peptide, and alterations in the ET-1 system are thought to play a role in triggering the vasoconstriction seen with preeclampsia. The aim of this study was to examine the frequency of the 4 common single-nucleotide polymorphisms (SNPs) (c.1370T>G, c.137_139delinsA, c.3539+2T>C, and c.5665G>T) of the ET-1 gene in normotensive and preeclamptic pregnancies and to investigate whether these SNPs are associated with preeclampsia in pregnant Korean women.

METHODS:

We analyzed blood samples from 206 preeclamptic and 216 normotensive pregnancies using a commercially available SNapShot kit and an ABI Prism 3100 Genetic analyzer.

RESULTS:

There were no significant differences in genotype or allele frequencies of the 4 SNPs in the ET-1 gene between preeclamptic and normotensive pregnancies. The respective frequencies of the 3 haplotypes (TDTG, GDCT, and TICT; >10% haplotype frequency) were 61%, 13% and 13%, respectively, in preeclampsic pregnancies and 62%, 14% and 12%, respectively, in normotensive pregnancies. The frequencies of these haplotypes were similar for both groups. Using multiple logistic regression analysis, we did not observe an increase in the risk of preeclampsia for the 4 SNPs of the ET-1 gene under either a recessive or dominant model.

CONCLUSION:

This study suggests that the 4 SNPs of the ET-1 gene are not associated with an increased risk for preeclampsia in pregnant Korean women.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pre-Eclampsia / Vasoconstriction / Haplotypes / Logistic Models / Endothelin-1 / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Perinatal Mortality / Gene Frequency / Genotype Type of study: Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Journal of Genetic Medicine Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pre-Eclampsia / Vasoconstriction / Haplotypes / Logistic Models / Endothelin-1 / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Perinatal Mortality / Gene Frequency / Genotype Type of study: Risk factors Limits: Female / Humans / Pregnancy Language: English Journal: Journal of Genetic Medicine Year: 2008 Type: Article