Neuromyelitis optica and neuromyelitis optica-IgG seropositivity in Saudis with demyelinating diseases of the central nervous system
Neurology Asia
;
: 295-300, 2014.
Article
in English
| WPRIM
| ID: wpr-628480
ABSTRACT
Background and Objective:
Neuromyelitis optica (NMO) shares certain features with multiple sclerosis (MS). Similar phenotypes, wide spectrum and the differential prevalence of NMO among ethnic backgrounds pose diagnostic challenges. NMO-IgG antibodies are specific biomarker for NMO and facilitate its differentiation from other demyelinating diseases. This study aimed to assess the frequency of NMO and NMO-IgG seropositivity in Saudi patients with demyelinating diseases of the central nervous system.Methods:
One hundred and four patients from neurology database at King Abdulaziz Medical City, Riyadh underwent clinical and laboratory examination, neuroimaging and NMO-IgG antibodies screening.Results:
The mean age at presentation was 32 (±9) years and there was an excess of females (femalemale – 31). The mean duration of illness was 4.6 (±3.2) years. During the illness, 48.1% of patients had clinical evidence of spinal cord involvement, 29.8% had optic neuritis and 14.4% had both features. A large majority (75.8%) of brain lesions fulfilled MRI criteria for MS and 17% had lesions extending over ≥3 vertebral segments. NMO-IgG antibodies were present in only one patient – a frequency of 0.96% in our study cohort.Conclusion:
Prevalence of NMO and NMO-IgG seropositivity is rare in Saudis with demyelinating diseases of the central nervous system. Hence, routine NMO-IgG testing is likely to have a low diagnostic yield
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Neurology Asia
Year:
2014
Type:
Article
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