The renin-angiotensin system and aging in the kidney
The Korean Journal of Internal Medicine
;
: 291-295, 2014.
Article
in English
| WPRIM
| ID: wpr-62923
ABSTRACT
Aging is associated with progressive functional deterioration and structural changes in the kidney. Changes in the activity or responsiveness of the renin-angiotensin system (RAS) occur with aging. RAS changes predispose the elderly to various fluid and electrolyte imbalances as well as acute kidney injury and chronic kidney disease. Among the multiple pathways involved in renal aging, the RAS plays a central role. This review summarizes the association of the RAS with structural and functional changes in the aging kidney and age-related renal injury, and describes the underlying mechanisms of RAS-related renal aging. An improved understanding of the renal aging process may lead to better individualized care of the elderly and improved renal survival in age-related diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Renin-Angiotensin System
/
Aging
/
Risk Factors
/
Age Factors
/
Acute Kidney Injury
/
Glucuronidase
/
Kidney
/
Kidney Diseases
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Animals
/
Humans
Language:
English
Journal:
The Korean Journal of Internal Medicine
Year:
2014
Type:
Article
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