The Efficacy of Tapering Treatment with 0.1% Tacrolimus Ointment in Adult Patients with Atopic Dermatitis in Korea / 대한피부과학회지
Korean Journal of Dermatology
;
: 314-319, 2014.
Article
in Korean
| WPRIM
| ID: wpr-62963
ABSTRACT
BACKGROUND:
Tacrolimus ointment is a topical immunomodulator. Preliminary studies suggest that 0.1% tacrolimus is effective and has a proactive effect on atopic dermatitis with fewer complications than topical corticosteroids.OBJECTIVE:
The purpose of this study was to evaluate the efficacy and safety of tapering treatment with 0.1% tacrolimus ointment and its impact on quality of life in adult patients with atopic dermatitis in Korea. Korean adults with atopic dermatitis.METHODS:
A total of 53 patients aged 15 to 54 years with moderate to severe atopic dermatitis applied 0.1% tacrolimus ointment for 12 weeks. The 0.1% tacrolimus ointment was applied along with a topical corticosteroid once daily during the 2-week induction phase and twice daily during the 2-week transitional phase. During the 8-week maintenance phase, the corticosteroid was discontinued and the 0.1% tacrolimus ointment alone was applied twice daily for 2 weeks and twice weekly for 6 weeks. Efficacy and quality of life were evaluated by the SCORAD and the Dermatology Life Quality Index (DLQI), respectively.RESULTS:
SCORAD and DLQI values were significantly improved after 12 weeks of treatment. Symptoms were markedly improved after 2 weeks of applying the 0.1% tacrolimus ointment and the improvements were well maintained after tapering. Continuous improvement was observed throughout the study. Transient skin burning and itching occurred in about 43% of the patients, but gradually decreased in about 30% after continuous application.CONCLUSION:
Tapering treatment with 0.1% tacrolimus ointment is safe and effective, and may replace the long-term use of topical corticosteroids, avoiding corticosteroid-associated adverse effects while maintaining clinical control and improving the quality of life of adult atopic dermatitis patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Quality of Life
/
Skin
/
Burns
/
Treatment Outcome
/
Tacrolimus
/
Adrenal Cortex Hormones
/
Dermatitis, Atopic
/
Dermatology
/
Korea
Limits:
Adult
/
Humans
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2014
Type:
Article
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