Tissue-engineered bone via seeding bone marrow stem cell derived osteoblasts into coral: a rat model
The Medical Journal of Malaysia
;
: 200-201, 2004.
Article
in Malayalam
| WPRIM
| ID: wpr-629963
ABSTRACT
In the present study, natural coral of porites species was used as scaffold combined with in vitro expanded bone marrow stem cell derived osteoblasts (BMSC-DO), to develop a tissue-engineered bone graft in a rat model. Coral was molded into the shape of rat mandible seeded with 5x10(6) /ml BMSC-DO subsequently implanted subcutaneously in the back of 5 week Sprague dawely rats for 3 months. Coral alone was implanted as a control. The implants were harvest and processed for gross inspection and histological observations. The results showed that newly bone grafts were successfully formed coral seeded with cells group showed smooth highly vascularized like bone tissue. Histological sections revealed mature bone formation and lots of blood vessel, the bone formation occurred in the manner resemble intramembraneous bone formation. This study demonstrates that coral can be use as a suitable scaffold material for delivering bone marrow mesenchymal stem cells in tissue engineering.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Culture Techniques
/
Osteoblasts
/
Biodegradation, Environmental
/
Calcium Carbonate
/
Bone Marrow Cells
/
Microscopy, Electron, Scanning
/
Bone Transplantation
/
Tissue Engineering
/
Anthozoa
/
Mesenchymal Stem Cells
Language:
Malayalam
Journal:
The Medical Journal of Malaysia
Year:
2004
Type:
Article
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