Infection associated haemophagocytic syndrome in severe dengue infection – a case series in a district hospital
The Medical Journal of Malaysia
;
: 62-64, 2017.
Article
in English
| WPRIM
| ID: wpr-630921
ABSTRACT
Haemophagocytic lymphohistiocytosis (HLH) is a potentially fatal disorder resulting from uncontrolled hyperinflammatory response. There had been increase in cases of one of the secondary form of HLH, i.e., infectionassociated haemophagocytic syndrome (IAHS) in severe dengue in recent years. However, the condition remains under diagnosed due to lack of awareness compounded by the lack of validated diagnostic criteria. Severe hepatitis with prolonged cytopenias, severe hyperferritinemia, hypofibrinogenemia and persistent fever were evident in all four cases reported. All the subjects survived with supportive care and adjuvant steroid therapy. Prospective controlled studies are needed to develop diagnostic criteria and management protocol for IAHS in severe dengue.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Severe Dengue
Type of study:
Practice guideline
Language:
English
Journal:
The Medical Journal of Malaysia
Year:
2017
Type:
Article
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